Late-phase synthesis of I B insulates the TLR4-activated canonical NF- B pathway from noncanonical NF- B signaling in macrophages

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

Signaling to NF - B

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis

CD40, a member of the tumor necrosis factor (TNF) receptor family, plays an essential role in T cell-dependent immune responses. Because CD40 is widely expressed on the surface of tumor cells in various B cell malignancies, deregulated CD40 signaling has been suggested to contribute to lymphomagenesis. In this study, we show that B cell-specific expression of a constitutively active CD40 recept...

A firm hand on NF B: structures of the I B –NF B complex

The regulation of gene expression, which allows a living cell to express a defined set of genes according to its environmental conditions and stage of development, occurs primarily at the level of transcription. The precise temporal and spatial control of the transcription factor NFκB has become a paradigm for the complexity of transcriptional regulation in eukaryotes. IκB, the inhibitor and ce...

Hypothermia enhances phosphorylation of I kappa B kinase and prolongs nuclear localization of NF-kappa B in LPS-activated macrophages

Hypothermia (HT) has been associated with both beneficial and detrimental consequences in various pathophysiologic states. While HT is generally thought to have anti-inflammatory and cytoprotective effects, we have previously shown that moderate in vitro HT prolongs TNFα production by LPS-stimulated mononuclear phagocytes, in part by prolonging TNFα gene transcription and activation of the plei...